Q. Wang

Ocrelizumab Modulates Both B and T Cell Immune Capacities in Multiple Sclerosis

This study examines how ocrelizumab affects B and T cell populations in MS patients, revealing changes in B cell subsets and T cell dynamics, along with altered signaling pathways.

CMTM6-Silencing Microbial Immunotherapy Reprograms PDAC Tumors and Restores T-cell Function

This paper develops iSTORM, a Salmonella-based immunotherapy that silences CMTM6 in PDAC tumors, enhancing T-cell function and tumor control while maintaining safety.

Cnidaria XIAP activates caspase-mediated cell death

This study investigates the function of XIAP in Cnidaria, showing it activates caspase-mediated cell death through BIR and RING domains, unlike its vertebrate counterpart.

Internal regulation between constitutively expressed T cell coinhibitory receptors BTLA and CD5 and tolerance in recent thymic emigrants

This study identifies a regulatory pathway between BTLA and CD5 in T cells that calibrates their expression to establish self-tolerance in recent thymic emigrants.

Omicron-specific ultra-potent SARS-CoV-2 neutralizing antibodies targeting the N1/N2 loop of Spike N-terminal domain

This study identifies ultra-potent Omicron-specific antibodies targeting the N1/N2 loop of the Spike NTD, which neutralize SARS-CoV-2 by competing with ACE2 and blocking S1 shedding, but are evaded by BA.2.86 and BA.2.87.1 sublineages.

HERV-derived epitopes represent new targets for T-cell based immunotherapies in ovarian cancer

This study identifies HERV-derived epitopes as potential targets for T-cell immunotherapies in ovarian cancer, showing their expression in tumors and immunogenicity in patients.

Strawberry COP9 signalosome FvCSN5A regulates plant development and fruit ripening by facilitating polyamine oxidase FvPAO5 degradation to control polyamine and H2O2 homeostasis

This study identifies FvCSN5A as a regulator of polyamine and H2O2 homeostasis in strawberries by controlling FvPAO5 degradation, affecting plant development and fruit ripening.

High-throughput drug screening for inhibition of influenza A virus infection based on human SIRT1 promoter and Genipin suppressing influenza A virus by activation of AMPK-SIRT1-PGC-1α signaling pathway

This study identifies Genipin and its derivatives as inhibitors of influenza A virus replication by activating the AMPK-SIRT1-PGC-1α signaling pathway and altering metabolic reprogramming.

Charge distribution and helical content tune the binding of septins amphipathic helix domain to lipid membranes

This study investigates how charge distribution and helical content of amphipathic helix domains affect septin binding to lipid membranes using simulations and experiments.

Physical constraints and biological regulations underlie universal osmoresponses

The paper develops a theory integrating physical constraints and biological regulations to explain universal osmoresponses in microorganisms, predicting growth thresholds and growth rate changes under osmotic stress.

Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis

This study shows aging reduces lung stem cell function and suppresses lung cancer by inducing iron deficiency through the NUPR1-lipocalin-2 pathway.

Nitazoxanide ameliorates OVA-induced airway inflammation in asthmatic mice via p38-MAPK/ NFκB and AMPK/STAT3 pathways

This study shows nitazoxanide reduces airway inflammation in asthmatic mice by inhibiting NFκB/MAPK and AMPK/STAT3 pathways.

Recurrent SARS-CoV-2 spike mutations confer growth advantages to select JN.1 sublineages

This study examines how recurrent spike mutations in SARS-CoV-2 JN.1 sublineages affect immune evasion, ACE2 affinity, and infectivity, identifying growth advantages in specific sublineages.

Targeting a shared neoepitope derived from non-canonical translation of c-MYC oncogene in cancer cells

The paper identifies a shared neoepitope from non-canonical c-MYC translation in cancer cells that activates T cells to kill tumors without harming normal cells.

SASH1 impairs melanin synthesis and metastasis by down-regulating the TGF-β signaling pathway

This study shows SASH1 reduces melanin synthesis and metastasis by suppressing TGF-β1 signaling through regulation of THBS1 in melanocytes.

Single-cell transcriptomics reveals immunosuppressive microenvironment and highlights stumor-promoting macrophage cells in Glioblastoma

This study uses single-cell transcriptomics to analyze GBM tumor microenvironment, identifying immunosuppressive macrophage subtypes and exhausted NK cells, suggesting therapeutic targets.

Scalable Production and Purification of Engineered ARRDC1-Mediated Microvesicles in a HEK293 Suspension Cell System

This study develops scalable methods to produce and purify engineered ARRDC1-mediated microvesicles (ARMMs) for gene therapy delivery, showing efficient production and in vivo biodistribution.

Ferroptosis mediates the progression of hyperuricemic nephropathy by activating RAGE signaling

This study shows ferroptosis contributes to hyperuricemic nephropathy by activating RAGE signaling, and inhibiting ferroptosis improves renal injury and fibrosis in a mouse model.

Fast adaptive super-resolution lattice light-sheet microscopy for rapid, long-term, near-isotropic subcellular imaging

This paper introduces Meta-rLLS-VSIM, a super-resolution microscopy technique that achieves near-isotropic resolution with reduced training time and data requirements.

STECode: an automated virulence barcode generator to aid clinical and public health risk assessment of Shiga toxin-producing Escherichia coli

STECode automates virulence barcode generation for Shiga toxin-producing E. coli to assess pathogenic potential from sequencing data.

Potent neutralization by a receptor binding domain monoclonal antibody with broad specificity for SARS-CoV-2 JN.1 and other variants

This study develops a monoclonal antibody that broadly neutralizes multiple SARS-CoV-2 variants, including JN.1, and shows its protective efficacy in mice.

Design of antigens to present a tumor-specific cryptic epitope

The paper designs antigens that present a tumor-specific cryptic epitope in the conformation recognized by mAb806, showing successful stabilization of the epitope in vitro.

Biologically informed machine learning modeling of immune cells to reveal physiological and pathological aging process

The paper constructs a transcriptomic atlas of immune cells across human lifespan and develops a biological age prediction model using scRNA-seq and bulk RNA-seq data.

Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells

This study shows that Piezo1 in intestinal L cells mechanically regulates GLP-1 production, affecting glucose tolerance and diabetes.

NPRL2 gene therapy induces effective antitumor immunity in KRAS/STK11 mutant anti-PD1 resistant metastatic non-small cell lung cancer (NSCLC) in a humanized mouse model

This study shows NPRL2 gene therapy reduces lung metastases in KRAS/STK11 mutant NSCLC in humanized mice by enhancing immune cell infiltration and reducing T cell inhibitory signals.

SARS-CoV-2 Omicron BA.2.87.1 Exhibits Higher Susceptibility to Serum Neutralization Than EG.5.1 and JN.1

This study compares the antibody evasion, ACE2 binding, and infectivity of SARS-CoV-2 BA.2.87.1 with EG.5.1 and JN.1, finding BA.2.87.1 has lower immune evasion and reduced infectivity.

The Rhizobial effector NopT targets Nod factor receptors to regulate symbiosis in Lotus japonicus

The paper shows that the rhizobial effector NopT interacts with Nod factor receptors NFR1 and NFR5 in Lotus japonicus to regulate symbiosis by cleaving NFR5 and being counteracted by NFR1 phosphorylation.

Deep Plasma Proteome Profiling by Modulating Single Nanoparticle Protein Corona with Small Molecules

This paper demonstrates that adding small molecules to plasma enhances nanoparticle protein corona diversity, significantly increasing the number of detectable proteins in plasma proteome profiling.

Single-cell transcriptome landscape of zebrafish liver reveals hepatocytes and immune cell interactions in understanding nonalcoholic fatty liver disease

The paper uses single-cell RNA sequencing to map zebrafish liver cell types and interactions, identifying macrophage subtypes and their role in nonalcoholic fatty liver disease.

Compartment-Specific Antibody Correlates of Protection to SARS-CoV-2 Omicron in Macaques

This study identifies compartment-specific antibody correlates of protection against SARS-CoV-2 Omicron in macaques, showing neutralizing antibodies in serum and antibody-dependent cellular phagocytosis in bronchiolar lavage are strongest correlates.