MYCN mediates cysteine addiction and sensitizes to ferroptosis
H. Alborzinia, A. F. Florez, S. Gogolin, L. M. Brueckner, C. Shao, M. Gartlgruber, M. Nadler Holly, M. Ziehm, F. Paul, S. Steinhauser, E. Bell, M. Shaikhkarami, S. Hartlieb, D. Dreidax, E. M. Hess, , F. Westermann
This study shows MYCN promotes cysteine addiction and ferroptosis resistance in neuroblastoma, identifying therapeutic targets for ferroptosis induction.
bioRxiv · Aug 10, 2021 · PreprintCancer Biology