C. Herrmann

Pathogen-prey-predator relations of avian raptors during epizootics of highly pathogenic avian influenza virus HPAIV H5N1 (clade 2.3.4.4b) in Germany

The paper investigates the impact of HPAIV H5N1 on avian raptors during epizootics in Germany, finding they act as both indicators of the virus and victims, with mixed outcomes for their population stability.

Elucidating the activation mechanism for GBP1 oligomerization

This study reveals the activation mechanism of GBP1 oligomerization through cryo-EM structures, showing nucleotide-dependent conformational changes drive dimerization, oligomerization, and membrane binding for pathogen encapsulation.

Highly pathogenic avian influenza causes mass mortality in Sandwich tern (Thalasseus sandvicensis) breeding colonies across northwestern Europe

This study reports mass mortality of Sandwich terns due to HPAI A(H5N1) in northwestern Europe, with over 17% of the breeding population dying and high chick mortality observed.

Genetic and Environmental interactions contribute to immune variation in rewilded mice

This study examines how genetics and environment interact to influence immune variation in rewilded mice, finding that genotype drives cytokine responses while genotype-environment interactions shape cellular composition.

GBP2 aggregates LPS and activates the caspase-4 inflammasome independent of the bacterial encapsulation factor GBP1

This paper shows GBP2 can trigger pyroptosis by aggregating free LPS and activating caspase-4, independent of GBP1's bacterial binding function.

Proteomic identification of the interactome of stalled ribosome nascent chain complexes translating the thylakoid membrane protein D1

The paper identifies the interactome of stalled ribosome nascent chain complexes translating the thylakoid membrane protein D1, revealing STIC2's role in cotranslational substrate delivery.

Chromatin accessibility combined with enhancer clusters activation mediates heterogeneous response to dexamethasone in myeloma cells

The paper investigates how chromatin accessibility and enhancer clusters mediate heterogeneous responses to dexamethasone in myeloma cells, showing epigenomic changes linked to transcriptional heterogeneity.

MYCN mediates cysteine addiction and sensitizes to ferroptosis

This study shows MYCN promotes cysteine addiction and ferroptosis resistance in neuroblastoma, identifying therapeutic targets for ferroptosis induction.

Beech tree masting explains the inter-annual variation in the fall and spring peaks of Ixodes ricinus ticks with different time lags

This study shows that beech tree masting explains the inter-annual variation in Ixodes ricinus tick peaks with different time lags, supporting the direct development hypothesis for the fall peak.

SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity

This study identifies SPINT2 as a regulator of SARS-CoV-2 infection, showing its negative correlation with viral expression and down-regulation in COVID-19 patients and chronic disease datasets.

Single-cell analyses reveal SARS-CoV-2 interference with intrinsic immune response in the human gut

This study identifies enterocytes as the main target of SARS-CoV-2 in the gut and shows the virus suppresses interferon signaling to evade immune response.

The DNA methylation landscape of multiple myeloma shows extensive inter- and intrapatient heterogeneity that fuels transcriptomic variability

This study examines DNA methylation heterogeneity in multiple myeloma, linking it to transcriptomic variability and poor patient outcomes through epigenetic and structural changes.

Viral-mediated ubiquitination impacts interactions of host proteins with viral RNA and promotes viral RNA processing

The paper identifies RNA-binding proteins as substrates of viral-mediated ubiquitination, showing that non-degradative ubiquitination enhances viral RNA processing and progeny production.

Formicine ants swallow their highly acidic poison for gut microbial selection and control

The paper shows formicine ants use their acidic poison to control microbial communities in their gut, inhibiting pathogens while promoting beneficial bacteria.

Automated screening by 3D light-sheet microscopy with high spatial and temporal resolution reveals mitotic phenotypes

The paper presents a workflow using 3D light-sheet microscopy and automated image processing to screen mitotic phenotypes in 3D cell cultures with high throughput.

Induced aneuploidy disrupts MCF10A acini formation and CCND1 expression

This study shows that induced aneuploidy disrupts MCF10A acini formation and upregulates CCND1 expression through altered promoter-enhancer interactions.