Arginine-dependent hypusination of the eukaryotic translation initiation factor (eIF)5A drives erythroid lineage differentiation
P. Gonzalez-Menendez, I. Phadke, M. E. Olive, K. L. McGraw, J. Platon, J. Papoin, H. Yan, M. Daumur, F. Paul, R. Mirmira, A. Joly, J. Galtier, A. Narla, G. Cartron, V. Dardalhon, , N. Taylor
The paper shows that arginine metabolism via hypusination of eIF5A regulates erythroid differentiation and that impaired eIF5A activity leads to erythroid disorders.
bioRxiv · Mar 21, 2022 · PreprintPhysiology