Drug-induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann-Pick type C cells and mice
D. Moreau, F. Vacca, S. Vossio, C. C. Scott, A. Colaco, J. Paz Montoya, C. Ferguson, M. Damme, M. Moniatte, R. G. Parton, F. M. Platt, J. Gruenberg
The paper identifies thioperamide as a drug that increases lysobisphosphatidic acid (LBPA) levels, reducing cholesterol overload in Niemann-Pick type C cells and mice.
bioRxiv · Mar 8, 2019Cell Biology