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S. Wiley

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Biochemistry· 1

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Approach:experimental assay· 1

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B. M. Hoffman· 1 shared C. D. James· 1 shared S. W. Ragsdale· 1 shared

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1 shared paperBiochemistry

B. M. Hoffman

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13C Electron Nuclear Double Resonance Spectroscopy Shows Acetyl-CoA Synthase Binds Two Substrate CO in Multiple Binding Modes and Reveals the Importance of a CO-Binding 'Alcove'

C. D. James, S. Wiley, S. W. Ragsdale, B. M. Hoffman

This paper uses 13C-ENDOR spectroscopy to show Acetyl-CoA Synthase binds two CO molecules in different modes, highlighting the role of an alcove in stabilizing the Ni(I)-CO intermediate.

bioRxiv · Jun 23, 2020Biochemistry