C. D. James

Fibroblast Stromal Support Model for Predicting Human Papillomavirus-Associated Cancer Drug Responses.

This paper develops a fibroblast co-culture model to predict drug responses in HPV+ cancers and shows it better predicts in vivo outcomes than in vitro alone.

E7-mediated repression of miR-203 promotes LASP1-dependent proliferation in HPV-positive cervical cancer

This study shows that HPV E7 represses miR-203, leading to LASP1 upregulation and promoting proliferation in HPV-positive cervical cancer.

Human Papillomavirus 16 replication converts SAMHD1 into a homologous recombination factor and promotes its recruitment to replicating viral DNA

This paper shows HPV16 replication converts SAMHD1 into a homologous recombination factor by phosphorylation, enhancing its recruitment to viral DNA and reducing replication.

The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer

This paper shows that MARCHF8 stabilizes HPV E7 by degrading CUL1 and UBE2L3, preventing E7 degradation in HPV+ HNC cells.

Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation function

This study shows that E2 protein interaction with BRD4's CTM and TopBP1 is essential for HPV16's mitotic chromatin association and plasmid segregation, offering therapeutic targets for viral genome targeting.

Human papillomavirus 16 E2 interaction with TopBP1 is required for E2 and viral genome stability during the viral life cycle.

This paper shows that HPV16 and HPV11 E2 proteins require interaction with TopBP1 for stability, and disrupting this interaction with CK2 inhibitors like CX4945 promotes viral genome integration and could be a therapeutic strategy.

HPV E6 upregulates MARCHF8 ubiquitin ligase and inhibits apoptosis by degrading the death receptors in head and neck cancer

WDR82 mediated H3K4me3 is associated with tumor proliferation and therapeutic efficacy in pediatric high-grade gliomas

The paper shows that WDR82-mediated H3K4me3 promotes tumor proliferation and affects therapeutic response in pediatric high-grade gliomas.

Ribonucleotide Reductase Regulatory Subunit M2 as a Driver of Glioblastoma TMZ-Resistance through Modulation of dNTP Production

This study identifies RRM2 as a driver of TMZ resistance in GBM by modulating dNTP production, showing RRM2 inhibition enhances TMZ efficacy in vivo.

Human papillomavirus 16 E2 repression of TWIST1 transcription is a potential mediator of HPV16 cancer outcomes

This paper shows that HPV16 E2 represses TWIST1 transcription, which may explain the better clinical outcomes in HPV16 positive cancers.

Neural Stem Cells Secreting Bispecific T Cell Engager to Induce Selective Anti-Glioma Activity

This study develops neural stem cells secreting a bispecific T cell engager (BiTE) to target glioblastoma, showing survival benefits in mice with IL13R2+ tumors.

13C Electron Nuclear Double Resonance Spectroscopy Shows Acetyl-CoA Synthase Binds Two Substrate CO in Multiple Binding Modes and Reveals the Importance of a CO-Binding 'Alcove'

This paper uses 13C-ENDOR spectroscopy to show Acetyl-CoA Synthase binds two CO molecules in different modes, highlighting the role of an alcove in stabilizing the Ni(I)-CO intermediate.

MSCs Successfully Deliver Oncolytic Virotherapy to Diffuse Intrinsic Pontine Glioma

This study shows that mesenchymal stem cells can deliver oncolytic virotherapy to DIPG tumors, significantly improving survival when combined with radiotherapy in preclinical models.

Estrogen attenuates the growth of human papillomavirus positive epithelial cells

This paper shows estrogen reduces growth of HPV-positive epithelial cells through two mechanisms, suggesting it could be a therapeutic for HPV+HNSCC.

Identifying predictors of HPV-related head and neck squamous cell carcinoma progression and survival through patient-derived models

This study identifies predictors of HPV-related head and neck squamous cell carcinoma progression and survival using patient-derived models and finds associations between mutational burden and E2F target dysregulation with clinical outcomes.

SAMHD1 regulates human papillomavirus 16 induced cell proliferation and viral replication during differentiation of oral keratinocytes.

This study shows that HPV16 regulates SAMHD1 expression in oral keratinocytes, and SAMHD1 deletion enhances viral replication and cell proliferation in HPV16-infected cells.

Interleukin-8/CXCR2 signaling regulates therapy-induced plasticity and enhances tumorigenicity in glioblastoma

This study shows IL-8 promotes cellular plasticity and therapeutic resistance in glioblastoma by altering epigenetic marks and enhancing cancer initiating cell properties.

Activation of dopamine receptor 2 (DRD2) prompts transcriptomic and metabolic plasticity in glioblastoma

This paper shows that dopamine receptor 2 activation in glioblastoma cells increases their growth, stemness, and metabolic activity, suggesting dopamine signaling as a therapeutic target.