Transcriptional immune suppression and upregulation of double stranded DNA damage and repair repertoires in ecDNA-containing tumors
M. S. Lin, S.-Y. Jo, J. Luebeck, H. Y. Chang, S. Wu, P. S. Mischel, V. Bafna
The paper identifies transcriptional correlates of ecDNA in tumors, showing upregulation of DNA repair and downregulation of immune pathways.
bioRxiv · Apr 24, 2023Cancer Biology