S. Wu

Generative Neural Spike Prediction from Upstream Neural Activity via Behavioral Reinforcement

This paper develops a reinforcement learning framework to predict downstream neural spike trains from upstream activity using behavioral rewards, achieving better behavioral performance than existing methods.

Integrated Analyses of Multi-omic Data Derived from Paired Primary Lung Cancer and Brain Metastasis Reveals the Metabolic Vulnerability as a Novel Therapeutic Target

This study integrates multi-omic data from lung cancer and brain metastases to identify mitochondrial metabolism as a therapeutic target in brain metastases.

A MSTNDel273C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia

This paper describes the creation of MSTNDel273C mutation with FGF5 knockout sheep using CRISPR/Cas9, resulting in skeletal muscle myofiber hyperplasia and a 'double-muscle' phenotype.

Enhanced Recognition of a Herbal Compound Epiberberine by a DNA Quadruplex-Duplex Structure

This paper investigates how epiberberine binds to a DNA quadruplex structure and shows how modifying the DNA structure enhances binding affinity, leading to a new method for extracting the compound from plant extracts.

Adipokinetic hormone signaling mediates the enhanced fecundity of Diaphorina citri infected by 'Candidatus Liberibacter asiaticus'

This study identifies adipokinetic hormone signaling as a key mediator of increased fecundity in CLas-infected D. citri, revealing a mutualistic interaction between the bacterium and the insect.

'Target-and-release' nanoparticles for effective immunotherapy of metastatic ovarian cancer

This study develops IL-12-loaded nanoparticles that enhance immunotherapy for metastatic ovarian cancer by promoting T cell accumulation and sensitizing tumors to checkpoint inhibitors.

Inhibition of serine racemase prevents diabetic retinopathy

This study shows that inhibiting serine racemase with L-ABH prevents diabetic retinopathy by protecting retinal cells and maintaining glucose homeostasis in diabetic mice.

Structural and mechanistic insights into Plasmodium eIF2alpha dephosphorylation by UIS2 during the erythrocytic stage

This paper identifies UIS2 as a critical phosphatase for Plasmodium proliferation during the erythrocytic stage and reveals its structural mechanism for eIF2alpha dephosphorylation, suggesting it as a target for antimalarial drugs.

Molecular basis of Ad5-nCoV Vaccine-Induced Immunogenicity

This study investigates the molecular basis of Ad5-nCoV vaccine-induced immunogenicity by analyzing the structure and properties of the spike antigens it induces.

Oligopeptide (FK)4 facilitates the determination of the absolute stereochemistry of chiral organic compounds via NMR Spectroscopy

This study demonstrates how the oligopeptide (FK)4 enables the determination of absolute stereochemistry of chiral compounds using NMR spectroscopy by combining alignment medium and chiral differentiating properties.

The tumor-maintaining function of UTX/KDM6A in DNA replication and the PARP1-dependent repair pathway

This paper identifies UTX/KDM6A's role in tumor maintenance through DNA replication and repair pathways, showing that targeting the protein, not just its enzymatic activity, could be a therapeutic strategy.

On the discovered Cancer Driving Nucleotides (CDNs)-Distributions across genes, cancer types and patients

This study identifies Cancer Driving Nucleotides (CDNs) across cancer types and patients, finding that most remain unidentified and highlights the need for larger sample sizes to improve detection.

Virulence of Fusarium oxysporum strains causing corneal or plant disease is associated with their accessory chromosomes

This study compares two Fusarium oxysporum strains causing human and plant diseases, finding differences in virulence and accessory chromosomes associated with host adaptation.

The ancient evolution of far-red light photoacclimation in cyanobacteria

This study identifies the ancient origin of far-red light photoacclimation in cyanobacteria using genomic data, showing its early evolutionary emergence and potential role in early Earth's environments.

pH-Controlled chemoselective rapid azo-coupling reaction (CRACR) enables global profiling of serotonylation proteome in cancer cells

The paper develops a chemical proteomic method to globally profile serotonylation in cancer cells, identifying over 1,000 serotonylated proteins and their modification sites.

Chemical proteomic profiling of protein dopaminylation in colorectal cancer cells

The paper identifies 425 dopaminylated proteins in colorectal cancer cells using a chemical probe, revealing their involvement in nucleic acid metabolism and transcription, and suggests targeting protein dopaminylation as a potential anti-cancer strategy.

CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

This study identifies convergent therapeutic targets for chemoresistance in cancer using CRISPR screens across multiple drug conditions and cancer models.

GoMartini 3: From large conformational changes in proteins to environmental bias corrections

This paper introduces an enhanced G[o]Martini model that improves protein dynamics simulation and addresses inaccuracies in the Martini protein model through diverse case studies.

A 10-valent composite mRNA vaccine against both influenza and COVID-19

This paper introduces FLUCOV-10, a 10-valent mRNA vaccine targeting influenza and SARS-CoV-2, showing robust immune responses and complete protection in mice against multiple strains.

Stimulated Prorocentrum donghaiense cell growth by in-situ mariculture dissolved organic matter

This study shows that in-situ mariculture dissolved organic matter promotes growth and photosynthesis of Prorocentrum donghaiense through absorbtrophy, with bacterioplankton playing helper and competitor roles.

Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease

This study tracks microbiome changes across four body sites in 86 participants over six years, revealing site-specific stability, individualized dynamics, and altered patterns in insulin-resistant individuals.

Single-Cell RNA-seq based elucidation of the antidepressant hyperforin biosynthesis de novo in St. John's wort.

The paper identifies Hyper cells in St. John's wort where hyperforin biosynthesis occurs de novo and characterizes four prenyltransferases involved in its synthesis.

Patient Subtyping Analysis of Baseline Multi-omic Data Reveals Distinct Pre-immune States Predictive of Vaccination Responses

The paper analyzes baseline multi-omic data from influenza vaccine recipients to identify pre-immune states predictive of vaccination responses.

Defining cell type-specific immune responses in a mouse model of allergic contact dermatitis by single-cell transcriptomics

This study uses single-cell transcriptomics to identify cell type-specific immune responses in a mouse model of allergic contact dermatitis, highlighting the role of dermal fibroblasts in type-1 inflammation.

Transient growth factor expression via mRNA in lipid nanoparticles promotes hepatocyte cell therapy to treat murine liver diseases

The paper demonstrates that transient mRNA-based growth factor expression in lipid nanoparticles enhances PHH engraftment and liver function in murine liver disease models.

Lateral Flow Assays Biotesting by Utilizing Plasmonic Nanoparticles Made of Inexpensive Metals - Replacing Colloidal Gold

This paper develops plasmonic nanoparticles made from inexpensive metals for lateral flow assays, showing they perform as well as or better than gold nanoparticles in biosensing.

Identification of a Novel Ferroptosis Inducer with Dual Modulatory Effects on GPX4 Activity and Stability

This study identifies MI-2, a novel GPX4 inhibitor that induces ferroptosis by inhibiting GPX4 activity and promoting its degradation, showing synergistic effects with existing cancer drugs.

Adaptive LDA classifier enhances real-time control of an EEG Brain-computer interface for imagined-speech decoding

This paper develops an adaptive LDA classifier for real-time EEG-based imagined speech decoding, showing improved performance compared to static classifiers.

Xanthomonas euvesicatoria effector XeAvrRxo1 triggers a Rxo1-mediated defense response in Nicotiana benthamiana and its chaperone Xe4429 functions as an antitoxin, an expression repressor, and an enhancer of XeAvrRxo1 secretion

This study identifies XeAvrRxo1 as a virulence and avirulence effector in X. euvesicatoria and shows that its chaperone Xe4429 suppresses toxicity, represses expression, and enhances secretion of XeAvrRxo1.

Developing folate-conjugated miR-34a therapeutic for prostate cancer treatment: Challenges and promises

This study evaluates folate-conjugated miR-34a as a potential prostate cancer therapeutic, finding limited efficacy due to low FOLR1 expression in prostate cancer cells.