Enhanced CB1 receptor function in GABAergic neurons mediates hyperexcitability and impaired sensory-driven synchrony of cortical circuits in Fragile X Syndrome model mice
D. Gonzalez, CR Jonak, Matteo Bernabucci, Gemma Molinaro, K. Collins, SA Assad, Jay R. Gibson, Devin K. Binder, Kimberly M. Huber
This study shows that reduced CB1 receptor function in GABAergic neurons of FXS model mice rescues cortical hyperexcitability and sensory-driven synchrony deficits.
Molecular Psychiatry · Nov 21, 2025Peer-reviewedNeuroscience