D. Gonzalez

Enhanced CB1 receptor function in GABAergic neurons mediates hyperexcitability and impaired sensory-driven synchrony of cortical circuits in Fragile X Syndrome model mice

This study shows that reduced CB1 receptor function in GABAergic neurons of FXS model mice rescues cortical hyperexcitability and sensory-driven synchrony deficits.

Exploring the role of EMT in Ovarian Cancer Progression: Insights from a multiscale mathematical model

This study uses a multiscale mathematical model to explore how EMT influences ovarian cancer progression in two cell lines, finding that EMT and cell cycle parameters significantly affect tumor dynamics.

A single Microcoleus species causes benthic cyanotoxic blooms worldwide

The paper identifies a single Microcoleus species, Microcoleus anatoxicus, as the cause of benthic cyanotoxic blooms in multiple regions worldwide.

Diurnal cycles drive rhythmic physiology and promote survival in facultative phototrophic bacteria

This study shows that diurnal light cycles drive rhythmic physiology in facultative phototrophic bacteria, enhancing survival under nutrient limitation.

Antibiotic potentiation and inhibition of cross-resistance in pathogens associated with cystic fibrosis

The paper identifies cell envelope protein homeostasis pathways as key to antibiotic resistance and cross-protection in CF-associated bacteria, showing potential for new treatment strategies.

Cardiac Effects of a Novel pH-Insensitive Sodium-Calcium Exchanger Mouse

This study creates a pH-insensitive NCX1 mouse and finds it has reduced growth, accelerated cardiac repolarization, and is resistant to ischemia/reperfusion injury.

Spatiotemporal coordination of stem cell behavior following alveolar injury

This study tracks alveolar type 2 stem cell behavior after injury using live imaging and identifies distinct motility states and their regulation.

A Zur-mediated transcriptional regulation of the zinc export system

This study reveals that Zur, a repressor of zinc import in Pseudomonas aeruginosa, also activates the zinc export system under Zn excess by regulating czcR transcription.

Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation

This study shows that oncogenic KrasG12D causes tissue deformation by converting pulsatile ERK signals into sustained activation, disrupting stem cell coordination in hair follicles.

Aerosolized Desert Dusts Collected Near a Drying Lake and Pulmonary Inflammation in Mice: Implications for Environmental Exposures and Asthma

This study examines the effects of Salton Sea playa dust on pulmonary inflammation in mice, finding acute neutrophil inflammation similar to innate immune responses.

Nutrients and flow shape the cyclic dominance games between Escherichia coli strains

This study combines experiments and modeling to show that nutrients and flow rates influence cyclic dominance among three Escherichia coli strains, with toxin retention predicting competition outcomes.

Autocrine Sfrp1 inhibits lung fibroblast invasion during transition to injury induced myofibroblasts

The paper identifies Sfrp1 as an autocrine inhibitor of fibroblast invasion during lung fibrosis by analyzing fibroblast states and signaling pathways in mouse lung regeneration.

Intracellular Calcium links Milk Stasis to Lysosome Dependent Cell Death by Activating a TGFbeta3/TFEB/STAT3 Pathway Early during Mammary Gland Involution

The paper shows that intracellular calcium, triggered by milk stasis, activates STAT3 via SOCS3 degradation and TFEB, leading to lysosome-dependent cell death during mammary gland involution.

Design and construction of 3D-printed devices to investigate active and passive bacterial dispersal on hydrated surfaces

This study designs 3D-printed devices to investigate bacterial dispersal on hydrated surfaces, showing that non-motile cells require flow or motile cells for dispersal.

An NKX-COUP-TFII genomic code for mucosal vascular addressins and organ morphogenesis

The paper identifies a genomic code involving NKX-COUP-TFII elements that regulate mucosal vascular addressin expression and organ morphogenesis.

KaiC-like proteins improve stress resistance in environmental Pseudomonas species

This study identifies KaiC-like proteins in environmental Pseudomonas species, showing their role in stress resistance and metabolic functions, with phosphorylation patterns linked to culture age rather than circadian rhythms.

Spatial scales of competition and a growth-motility tradeoff interact to determine bacterial coexistence

This study shows that spatial competition scales and a growth-motility tradeoff influence bacterial coexistence, with regional competition and dispersal networks promoting coexistence.

Breaking antimicrobial resistance by disrupting extracytoplasmic protein folding

This paper shows that disrupting disulfide bond formation in Gram-negative bacteria sensitizes them to antibiotics by impairing resistance proteins.

In-solution buffer-free digestion for the analysis of SARS-CoV-2 RBD proteins allows a full sequence coverage and detection of post-translational modifications in a single ESI-MS spectrum

This paper introduces an in-solution buffer-free digestion method for analyzing SARS-CoV-2 RBD proteins, achieving full sequence coverage and detecting post-translational modifications in a single ESI-MS spectrum.

Comparative Analysis of T Cell Spatial Proteomics and the Influence of HIV Expression

The paper compares machine learning methods for spatial proteome classification in HIV-expressing T cells and identifies Nef-dependent interactors.

Sequence-unrelated long noncoding RNAs converged to modulate the activity of conserved epigenetic machineries across kingdoms

The paper shows that sequence-unrelated lncRNAs modulate epigenetic machineries across kingdoms by interacting with conserved proteins to regulate gene expression.

A combined EM and proteomic analysis places HIV-1 Vpu at the crossroads of retromer and ESCRT complexes: PTPN23 is a Vpu-cofactor

This paper identifies PTPN23 as a Vpu-cofactor and maps Vpu's interactions with retromer and ESCRT complexes using EM and proteomics.

The DEAD-box RNA helicases RhlE2 is a global regulator of Pseudomonas aeruginosa lifestyle and pathogenesis

This study identifies RhlE2 as a global post-transcriptional regulator in Pseudomonas aeruginosa that affects hundreds of transcripts and is essential for virulence and environmental adaptation.

Droplet printing reveals the importance of micron-scale structure for bacterial ecology

The paper develops a droplet printing method to study bacterial ecology by manipulating spatial arrangements of E. coli strains and shows how micron-scale structure affects competition and coexistence.

Local frustration determines loop opening during the catalytic cycle of an oxidoreductase

This study shows how oxidation of cysteine thiols to a disulfide bond in DsbD introduces local frustration, disrupting the cap-loop structure and enabling loop opening during its catalytic cycle.

Targeted Sequencing Workflows for Comprehensive Drug Resistance Profiling of Mycobacterium tuberculosis cultures using Illumina MiSeq and Nanopore MinION: Comparison of analytical and diagnostic performance, turnaround time and cost

This paper compares two sequencing workflows for drug resistance profiling of M. tuberculosis using Illumina MiSeq and Nanopore MinION, finding comparable accuracy with differences in speed and cost.

The conserved transcriptional regulator CdnL is required for metabolic homeostasis and morphogenesis in Caulobacter

This study shows that CdnL is essential for metabolic homeostasis and morphogenesis in Caulobacter crescentus by regulating biosynthetic gene expression and lipid II production.

The Relationship Between the Cervical Microbiome, HIV Status, and Pre-Cancerous Lesions

The study examines the cervical microbiome in Tanzanian women, finding higher bacterial richness in HIV-positive individuals and those with high-grade squamous intraepithelial lesions.