A scalable in vitro cell competition model identifies preleukemic super competitor clones
Lilia Cabrera-Cosme, Juan A. Rubio-Lara, Ellie Bennett, Joanna Milek, Chöle Baldreki, Adam Dowle, M. S. Vijayabaskar, Sophie J Davies, Ewan Taylor-Smith, Fiona M. Bain, Sandy J. Macdonald, Sally James, Karen Hogg, Maria Jassinskaja, Berthold Göttgens, , David G. Kent
This study develops an in vitro clonal competition model to identify preleukemic TET2-mutant clones that suppress wild-type cells through RAC1-GEF signalling inhibition.
bioRxiv · Oct 22, 2026 · PreprintCancer Biology