Adam Dowle

This study maps the dynamic phosphoproteome of Leishmania during differentiation, revealing stage-specific kinase roles in cytokinesis and showing how flagellar motility buffers MPK2 dependency.

This study develops an in vitro clonal competition model to identify preleukemic TET2-mutant clones that suppress wild-type cells through RAC1-GEF signalling inhibition.

This study identifies a pH-dependent kinase cascade in Leishmania that regulates differentiation into infectious stages, revealing key pathways for acid adaptation and transmission.

This paper investigates why aryl sulfatases are inhibited by sulfamate warheads while carbohydrate sulfatases are not, using structural and computational analyses.

This study characterizes the pyrenoid structure and molecular components of Chlorella sorokiniana, revealing conserved inorganic carbon delivery machinery and novel proteins involved in pyrenoid assembly and starch tethering.

This study identifies MBD1-L, an aberrantly spliced transcript in MDS, which drives epigenetic changes leading to myeloerythroid defects, and shows ASO-based targeting can restore erythroid differentiation.

This study maps the Leishmania ubiquitinome and identifies DUB2 as a key regulator of differentiation by modulating ubiquitination of proteins involved in cell motility and metabolism.

The paper identifies three proteins that negatively regulate ESAG transcripts through specialised RNA decay in Trypanosoma brucei, revealing a novel post-transcriptional regulatory mechanism.

The paper uses multimodal imaging and single-cell transcriptomics to identify LPCAT2-mediated membrane remodeling in granuloma macrophages during visceral leishmaniasis.

This paper shows that AURKB drives the dissolution of CIZ1-RNA assemblies from the inactive X chromosome during mitosis by phosphorylating CIZ1's C-terminal extensions, disrupting its RNA interactions.

This study shows that the androgen receptor and MYC work together to control the production of Siglec-7 ligands in prostate cancer by regulating sialylation and glycopeptide profiles.

This paper identifies and validates cell-permeable inhibitors of Leishmania mexicana CLK1 using a BRET-based assay, showing WZ8040 effectively targets CLK1 with minimal host toxicity.

This study identifies MSK as a kinase essential for coordinating nucleus and kinetoplast segregation in Leishmania mexicana, showing its role in mitotic spindle function and cell survival.

DIANNeR improves detection of GR interactomes in normal tissues by integrating DIA, ion mobility, and library-free analysis, revealing context-specific networks and previously undetected interactions.

The paper introduces CyanoTag, a high-throughput method for endogenous fluorescent protein tagging in Synechococcus elongatus, enabling subcellular localization, protein abundance tracking, and interaction network analysis of over 330 proteins.

The paper identifies a conserved long non-coding RNA in Leishmania braziliensis and shows its structural importance for parasite fitness and RNA-protein interactions.

The paper identifies a protein interaction network in the diatom pyrenoid, revealing a structural shell critical for CO2 fixation and suggesting convergent evolution with prokaryotic carboxysomes.

The paper identifies PRMT7 as an epigenetic regulator in Leishmania that modifies RNA-binding proteins, affecting mRNA stability and virulence.

This study identifies 1,400 mRNA binding proteins in Leishmania mexicana across three lifecycle stages, revealing stage-specific RNA binding and limited correlation between mRNA levels and protein expression.