An Improved Systematic Method for Constructing ecGEMs using a Protein-Chemical Transformer
Anna Schooneveld, Shafiat Dewan, Navot Arad, Sam Genway, Sonya Kaur Kalsi, Kotryna Bloznelyte, Will Addison, David Berman
The paper introduces a transformer-based method to predict kcat values for E. coli enzymes, improving ecGEMs with fewer calibrations and better performance than existing models.
bioRxiv · Oct 29, 2025 · PreprintSystems Biology