Sam Yacoub

Genetic and pharmacological correction of impaired mitophagy in retinal ganglion cells rescues glaucomatous neurodegeneration

The paper shows that impaired mitophagy in retinal ganglion cells contributes to glaucomatous neurodegeneration and that pharmacological or genetic correction can rescue this damage.

Impaired axonal transport at the optic nerve head contributes to neurodegeneration in a novel Cre-inducible mouse model of myocilin glaucoma

This study develops a novel Cre-inducible mouse model of myocilin glaucoma that replicates key human disease features, showing impaired axonal transport precedes retinal ganglion cell loss.