Author

Samar Ghorbanpoor

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Aaron N. HataiD· 1 shared Anna E. MaciagiD· 1 shared Bin Wang· 1 shared Cathy ZhangiD· 1 shared Daniel AndrussieriD· 1 shared Emily Hensley· 1 shared Frank P. McCormickiD· 1 shared Grace Kelley· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Aaron N. HataORCID

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1 paper

Recent·Most cited

Dual inhibition of GTP-bound (ON) and GDP-bound (OFF) KRASG12C suppresses PI3Kα and leads to potent tumor inhibition

Katherine Parker, Samar Ghorbanpoor, Wafa Malik, Lauren Highfield, Jamie Wang, Emily Hensley, Grace Kelley, Sarah Clark, Michela Ranieri, Soumyadip Sahu, Cathy Zhang, Magdalena A. Ploszaj, Daniel Andrussier, Hsin‐Yi Huang, Ting Chen, , Aaron N. Hata

This study shows that a dual inhibitor of KRASG12C in both ON and OFF states more effectively suppresses tumor growth than an OFF-specific inhibitor by reducing PI3K-AKT activation.

bioRxiv · Apr 30, 2026 · PreprintCancer Biology