Bin Wang

Hydroxy polyethylene glycol: a solution to evade human pre-existing anti-PEG antibodies for efficient delivery

This study shows that hydroxy PEG (OH-PEG) reduces binding to pre-existing anti-PEG antibodies, improving stability and reducing immunogenicity of PEGylated nanomedicines.

TBI-166 inhibits DlaT and LpdC, exhibiting synergistic effects with Bedaquiline and Pyrazinamide against Mycobacterium tuberculosis

This paper evaluates a three-drug regimen combining TBI-166, bedaquiline, and pyrazinamide against Mycobacterium tuberculosis, showing synergistic effects and metabolic disruption.

Dual inhibition of GTP-bound (ON) and GDP-bound (OFF) KRASG12C suppresses PI3Kα and leads to potent tumor inhibition

This study shows that a dual inhibitor of KRASG12C in both ON and OFF states more effectively suppresses tumor growth than an OFF-specific inhibitor by reducing PI3K-AKT activation.

A correlational study of ABCA3 and SCN4B as exercise-related biomarkers of patients with Stanford type A aortic dissection

This study identifies ABCA3 and SCN4B as exercise-related biomarkers for Stanford type A aortic dissection and suggests potential therapeutic drugs.

MERFISH 2.0, an ultra-sensitive single-cell spatial transcriptomics imaging chemistry across diverse tissue types

MERFISH 2.0 improves transcript detection sensitivity in degraded and archival tissues, enhancing spatial transcriptomic analysis of human and mouse samples.

Identification of mutations associated with Macozinone-resistant in Mycobacterium Tuberculosis

The paper identifies mutations conferring resistance to Macozinone in Mycobacterium tuberculosis through in vitro selection and whole genome sequencing.

Identification of Novel and Differentially Expressed MicroRNAs in Goat Enzootic Nasal Adenocarcinoma

This study identifies novel and differentially expressed microRNAs in goat enzootic nasal adenocarcinoma tissues using small RNA sequencing.