Sarah Clark

The paper identifies a unique T-cell inflammatory signature in AGA+ schizophrenia-related disorder patients using scRNA-seq, linking it to increased severity of negative symptoms.

This study shows that a dual inhibitor of KRASG12C in both ON and OFF states more effectively suppresses tumor growth than an OFF-specific inhibitor by reducing PI3K-AKT activation.

This study optimizes single molecule assays to detect and quantify the native hair cell mechanosensory transduction complex at attomole levels.

This study determines the structure of the LPD-3 BLTP complex and reveals its mechanism for bulk lipid transfer through interactions with Intake and Spigot proteins.

The paper presents the cryo-EM structure of the C. elegans TMC-2 complex and compares it to the TMC-1 complex to identify structural features involved in mechanosensory transduction.

The paper identifies three structural populations of GABAARs in mice, revealing how neurosteroids modulate receptor structure and function.

This study uses cryo-electron tomography to visualize the molecular structure and conformation of tip-links in mouse stereocilia, revealing their stoichiometry and clustering.