Author

Sarah Barton

Lawrence Berkeley National LaboratoryPrimary ORCID profile (0000-0001-7077-0906 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Sarah BartoniD2 papers · Royal Children's Hospital

Biology Disciplines

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Genomics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Catherine S. Novak· 3 shared Erik Beckman· 3 shared Ingrid Plajzer-Frick· 3 shared Jennifer A. AkiyamaiD· 3 shared Kianna von Maydell· 3 shared Len A. PennacchioiD· 3 shared Michael KosickiiD· 3 shared Momoe KatoiD· 3 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenomics

Catherine S. Novak

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3 papers

Recent·Most cited

Uncovering Hidden Enhancers Through Unbiased In Vivo Testing

Brandon J. Mannion, Stella Tran, Ingrid Plajzer-Frick, Catherine S. Novak, Veena Afzal, Jennifer A. Akiyama, Ismael Sospedra, Sarah Barton, Erik Beckman, Tyler H. Garvin, Patrick Godfrey, Janeth Godoy, Riana D. Hunter, Momoe Kato, Michael Kosicki, , Len A. Pennacchio

The paper identifies hidden enhancers in mouse embryos that are not detected by conventional chromatin profiling methods, highlighting a significant gap in enhancer discovery.

Nature Communications · Aug 7, 2025Peer-reviewedGenomics

Mutagenesis Sensitivity Mapping of HumanEnhancers In Vivo

Michael Kosicki, Boyang Zhang, Vivian C. Hecht, Anusri Pampari, Laura Cook, Neil Slaven, Jennifer A. Akiyama, Ingrid Plajzer-Frick, Catherine S. Novak, Momoe Kato, Stella Tran, Riana D. Hunter, Kianna von Maydell, Sarah Barton, Erik Beckman, , Len A. Pennacchio

The paper maps the mutagenic sensitivity of human enhancers in vivo by systematically mutating enhancer sequences and using predictive modeling to identify critical nucleotides.

Nature · Jun 18, 2025Peer-reviewedGenomics

Massively parallel reporter assays and mouse transgenic assays provide complementary information about neuronal enhancer activity

Michael Kosicki, Dianne Laboy Cintrón, Nicholas F. Page, Ilias Georgakopoulos‐Soares, Jennifer A. Akiyama, Ingrid Plajzer-Frick, Catherine S. Novak, Momoe Kato, Riana D. Hunter, Kianna von Maydell, Sarah Barton, Patrick Godfrey, Erik Beckman, Stephan Sanders, Len A. Pennacchio, Nadav Ahituv

The paper combines massively parallel reporter assays and mouse transgenic assays to study the functional impact of non-coding variants on neuronal enhancer activity, finding strong correlations and additional pleiotropic effects.

bioRxiv · Apr 22, 2024 · PreprintGenomics