Female microglia show heightened responses to aging and amyloid pathology in mice and humans
Jillian E. J. Cox, Ewa Poljanska, Sarah Ray, Mallory Forsgren, Sung-Hwan Ko, Patrycja Świergiel, Zsabre Wright, Manu A. Thomas, Willard M. Freeman, Claire Delpirou Nouh, Heather C. Rice, Sarah R. Ocañas
The paper identifies conserved sex-biased microglial responses to aging and amyloid pathology in mice and humans using single-cell transcriptomics and proteomics.
bioRxiv · Oct 19, 2026 · PreprintNeuroscience