Author

Sasha Bailey

The Francis Crick Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

Erik A. SahaiiD· 4 shared Steven HooperiD· 4 shared A. M. I. Le MaroisiD· 2 shared Alexandrine CarminatiiD· 2 shared Charles SwantoniD· 2 shared Karin SchlegelmilchiD· 2 shared P. M. W. FrenchiD· 2 shared Sunil KumariD· 2 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersCancer Biology

Erik A. SahaiORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cooperative and antagonistic interactions between sub-clones favour the co-existence of multiple resistance mechanisms in melanoma

Karin Schlegelmilch, Viola Hollek, Steven Hooper, Giovanni Giangreco, Sasha Bailey, Sarah Macfarlane, Alexandrine Carminati, Amy L. Bowes, Stephanie Strohbuecker, Benjamin Shum, Samra Turajlic, Xiao Fu, Erik A. Sahai

This study shows that cooperative and antagonistic interactions between sub-clones in melanoma allow multiple resistance mechanisms to coexist, and identifies GSK-J4 as a potential therapeutic target.

bioRxiv · Oct 23, 2025 · PreprintCancer Biology

Splenic granulopoiesis and S100A9 drive resistance to checkpoint inhibitors conferred by liver metastases

Rebecca J. Lee, Steven Hooper, Laura J. Pallett, Mariana O. Diniz, Tate Mckinnon-Snell, Zoe Ramsden, Nicolas Rabas, Stefan Boeing, Oliver John Kennedy, Charlotte Buttercase, Gloryanne Aidoo-Micah, Gareth J. Price, Sarah C. Macfarlane, Sasha Bailey, Jessica E. Davies, , Erik A. Sahai

This study shows liver metastases reduce checkpoint inhibitor efficacy by increasing splenic granulopoiesis and S100A9hi neutrophils, which suppress T-cell responses, and demonstrates that targeting S100A9 restores efficacy.

bioRxiv · Sep 30, 2025 · PreprintImmunology

Cell migration sculpts evolutionary dynamics favouring therapy resistance in lung cancer

Ajay Bhargava, Xiao Fu, Sasha Bailey, Yutaka Naito, Hamid Mohammadi, Robert E. Hynds, Steven Hooper, Dhruva Biswas, Alix Le Marois, Sunil Kumar, Yuriy Alexandrov, P. M. W. French, James McGinty, Paul A. Bates, Charles Swanton, Erik A. Sahai

This study shows that cell migration and stromal fibroblasts influence subclone competition in lung cancer, promoting therapy resistance through increased cell mixing.

bioRxiv · Sep 15, 2025 · PreprintCancer Biology

Imaging of MAP kinase dynamics reveals endocytic regulation of pulsatile signalling and network re-wiring in response to targeted therapy in EGFR-mutant non-small cell lung cancer

A. M. I. Le Marois, Sasha Bailey, Steven Hooper, Sunil Kumar, Hugh Sparks, Yuriy Alexandrov, Deborah R. Caswell, Fabian Fröhlich, Karin Schlegelmilch, Karishma Valand, Matthew J. Martin, A. J. Narvaez, Charles Swanton, Julian Downward, Christopher W. Dunsby, , Erik A. Sahai

The paper uses single-cell imaging to show that drug-tolerant cells in EGFR-mutant lung cancer rewired ERK signaling through endocytic pathways and adhesion complexes, driven by YAP and PTPRS.

bioRxiv · May 14, 2024 · PreprintCancer Biology