ImmunologybioRxivPreprint
Human hepatic stellate cells orchestrate the accumulation and function of CD103+ tissue-resident CD8+ T-cells in liver fibrosis
George E. Finney, Daniel Brown Romero, Ginevra Pistocchi…·Laura J. Pallett
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University College LondonORCID 0000-0002-4161-9462Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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George E. Finney, Daniel Brown Romero, Ginevra Pistocchi…·Laura J. Pallett
Rebecca J. Lee, Steven Hooper, Laura J. Pallett…·Erik A. Sahai
This study shows liver metastases reduce checkpoint inhibitor efficacy by increasing splenic granulopoiesis and S100A9hi neutrophils, which suppress T-cell responses, and demonstrates that targeting S100A9 restores efficacy.