Robert E. Hynds

This study shows that the TGF-β1/mTORC1 signalling axis regulates the transcriptional identity of CTHRC1+ fibroblasts in IPF, supporting mTORC1 as a therapeutic target.

This study shows that p63 regulates stem cell function in human airway basal cells and declines with age, contributing to functional decline and reduced regenerative capacity.

This study identifies neutrophil myeloperoxidase (MPO) as a biomarker for RSV severity and demonstrates its utility as a functional readout for evaluating antiviral therapies in an in vitro model.

The paper presents a donor-derived air-liquid interface model for screening antiviral combinations against RSV, with tools to assess efficacy and epithelial toxicity.

This study identifies podoplanin (PDPN) as a marker for human airway basal cells with high progenitor potential, enabling efficient sorting of airway stem cells.

This study shows that cell migration and stromal fibroblasts influence subclone competition in lung cancer, promoting therapy resistance through increased cell mixing.

The paper introduces WS6 to enhance ex vivo expansion and gene editing of epithelial basal stem cells, enabling disease modeling and regenerative medicine applications.

The paper screens 1,429 compounds in primary human airway basal cells to identify Wnt pathway activators that promote proliferation and regeneration.

This study identifies RAS-PI3K signaling as a key regulator of myofibroblastic CAF identity and matrix competence in lung cancer, showing its role in restraining immunomodulatory stromal programs.

This study uses PET imaging to assess NRF2 activation in NSCLC, showing [18F]FSPG as a marker of therapeutic resistance and a potential target for treatment.

This paper develops lentiviral reporter constructs to quantitatively monitor airway epithelial cell differentiation using bioluminescence in vitro.