Cellular and molecular events organizing the assembly of tertiary lymphoid structures in glioblastoma
Alessandra Vaccaro, Fan Yang, Tiarne van de Walle, Saskia Franke, Roberta Lugano, Anna Dénes, Anastasia Magoulopoulou, Inés Cid-Fariña, Anja Smits, Lene Uhrbom, Sylwia Libard, Francesco Latini, Magnus Essand, Mats F. Nilsson, Liqun He, , Anna Dimberg
This study identifies cellular and molecular mechanisms of tertiary lymphoid structure (TLS) formation in glioblastoma, showing TLS correlate with improved survival and are driven by CD4 T cells expressing lymphotoxin β.
bioRxiv · Jul 4, 2024 · PreprintCancer Biology