Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis
Xueqian Zhuang, Qing Wang, Simon Joost, Alexander Ferrena, David T. Humphreys, Zhuxuan Li, Melissa Blum, Klavdija Krause, Selena Ding, Yuna Landais, Yingqian Ada Zhan, Yang Zhao, Ronan Chaligné, Joo‐Hyeon Lee, Sebastian E. Carrasco, , Tuomas Tammela
This study shows aging reduces lung stem cell function and suppresses lung cancer by inducing iron deficiency through the NUPR1-lipocalin-2 pathway.
Nature · Dec 4, 2024Peer-reviewedCancer Biology