Author

Simon Joost

Memorial Sloan Kettering Cancer CenterORCID 0000-0001-6661-541XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Tuomas TammelaiD· 2 shared Xueqian ZhuangiD· 2 shared Zhuxuan LiiD· 2 shared Alexander FerrenaiD· 1 shared Anupriya SinghaliD· 1 shared Charles M. RudiniD· 1 shared Chun‐Hao PaniD· 1 shared David T. HumphreysiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Tuomas TammelaORCID

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2 papers

Recent·Most cited

Cancer BiologyNaturePeer-reviewedDec 4, 2024

Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis

Xueqian Zhuang, Qing Wang, Simon Joost…·Tuomas Tammela

This study shows aging reduces lung stem cell function and suppresses lung cancer by inducing iron deficiency through the NUPR1-lipocalin-2 pathway.

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mouseDNA methylation

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Cancer BiologyCancer DiscoveryPeer-reviewedNov 6, 2023

Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma

Zhuxuan Li, Xueqian Zhuang, Chun‐Hao Pan…·Tuomas Tammela

This study shows that KRAS inhibition in lung adenocarcinoma leads to an AT1-like cell state that drives resistance, and targeting these cells improves treatment response.

79 citationstop 1%

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