Methionine metabolism and the NOP2 methyltransferase are essential for MYC-Driven liver tumorigenesis.
Sensen Lin, Charles A. Berdan, Moriah Sandy, Xinjun Lu, Vijay Ramani, Daniel K. Nomura, Xin Chen, Joyce V Lee, Andrei Goga
This study identifies methionine metabolism and the NOP2 methyltransferase as critical for MYC-driven liver tumorigenesis, suggesting NOP2 as a potential therapeutic target.
bioRxiv · Jan 30, 2026 · PreprintCancer Biology