Lineage-Specific Neofunctionalization of Polyacetylene-Directing UGT76 Glycosyltransferases in Campanulaceae
Shi Qiu, Jiadong Hu, Xue Cao, Min He, Chunhui Wang, Peng Di, Shanshan Chen, C H I Zhang, Ying Xiao, Renjun Mao, Wei Sun, Wansheng Chen
The paper identifies and characterizes UGT76 glycosyltransferases in Codonopsis pilosula that catalyze the biosynthesis of polyacetylene glycosides, revealing a novel tunnel-based substrate recognition mechanism.
bioRxiv · Jul 3, 2026 · PreprintEvolutionary Biology