A novel dephosphorylation peptide inhibits 17β-HSD1 enzyme activity in ovarian granulosa cells and breast cancer cells
Feng Yang, Haoyi Feng, Shanshan Chen, Xuanjun Liu, Tong Yu, Yizhao Li, Hao Wu, Shenming Zeng, Xuelei Han, Jie Lian, Kejun Wang, Xinjian Li
This study identifies phosphorylation sites in 17β-HSD1 and develops cell-penetrating peptides that inhibit its activity, reducing breast cancer cell proliferation and tumor growth.
bioRxiv · Dec 29, 2025 · PreprintCell Biology