APOE knockout attenuates vascular graft fibrosis by limiting profibrotic macrophage formation through low-density lipoprotein receptor related protein 1
Jiayin Fu, Meng Zhao, Jing Zhao, Shaofei Wu, Jiahui Wu, Xulin Hong, He Huang, Guosheng Fu, Shengqian Xu
This study shows that APOE knockout reduces vascular graft fibrosis by limiting profibrotic macrophage formation through LRP1, improving aortic compliance and reducing ECM deposition.
bioRxiv · Jul 22, 2025 · PreprintBioengineering