Shaya Lev

Direct voltage imaging of peripheral axons in vivo reveals ongoing nociceptor firing in healthy mice

The paper uses voltage imaging to show ongoing action potential firing in nociceptor terminals in healthy mice, revealing electrical activity in peripheral axons.

TRPV1-Mediated Delivery of Chloroprocaine, a Local Anesthetic with High pKa, Produces Pain-Selective Anesthesia Without Neurotoxicity

This study shows that chloroprocaine, a high-pKa local anesthetic, when delivered via TRPV1 channels, provides prolonged pain-selective anesthesia without neurotoxicity.

Efferent signaling along nociceptive peripheral terminals in vivo is enhanced during inflammation

The paper demonstrates that efferent signaling along nociceptive terminals increases during inflammation, leading to enhanced calcium signaling and mediator release in remote terminals.

Adaptation of pain-related projection neurons in acute but not chronic pain

The paper shows that spinal projection neurons reduce excitability during acute pain but not chronic pain, preventing pain chronification through increased potassium currents.

Age-dependent decrease in inhibitory drive on the excitatory superficial spinal dorsal horn neurons

The paper shows that aging reduces inhibitory drive on excitatory spinal dorsal horn neurons, potentially contributing to increased pain sensitivity in older mice.

Attenuation of colitis-induced visceral hypersensitivity and pain by silencing TRPV1-expressing fibers in rat colon

This study shows that silencing TRPV1-expressing fibers reduces colitis-induced visceral pain in rats by using QX-314 with TRPV1 activators or blockers.

Structural plasticity of axon initial segment in spinal cord neurons underlies inflammatory pain

The paper shows inflammation causes a distal shift of the axon initial segment in inhibitory spinal cord neurons, reducing their excitability and contributing to pain.

Encoding of inflammatory hyperalgesia in mice spinal cord

The paper investigates how spinal cord networks in mice encode inflammatory hyperalgesia through changes in neuronal activity and synaptic inhibition.

The input-output relation of primary nociceptive neurons is determined by the morphology of the peripheral nociceptive terminals

The paper shows that the input-output relation of primary nociceptive neurons depends on the morphology of their peripheral terminals and how multiple terminals integrate noxious stimuli.