Author

Shiwei Wang

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Neuroscience· 2 Biochemistry· 1 Cell Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Assay:proteomics· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Edward S. BoydeniD· 2 shared Laura L. KiesslingiD· 2 shared Alexi G. ChoueiriiD· 1 shared Alice E. StantoniD· 1 shared Amauche Emenari· 1 shared Andrés VillegasiD· 1 shared Camille Marie MitchelliD· 1 shared Carles A. BoixiD· 1 shared

Activity by Year

2025-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

Edward S. BoydenORCID

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Author profile →

5 papers

Recent·Most cited

Spatiotemporal atlas resolves the mesenchymal-epithelial stem cell axis governing human hair follicle aging and pathology

Xiaoyu Wei, Yanwen Xu, Jiaxin Du, Ruikang Li, Zhentao Zhou, Yeya Yu, Zishuo Yuan, Hanxiao Cheng, Yujia Jiang, Fei Zhu, Pengfei Cai, Haiyan Shen, Shuai Wang, Yue Yuan, Xiawei Liu, , Jufang Zhang

This study creates a spatiotemporal atlas to understand mesenchymal-epithelial stem cell dynamics in human hair follicle aging and androgenetic alopecia, identifying PTN as a key regenerative factor.

bioRxiv · Sep 23, 2026 · PreprintCell Biology

Astrocyte-driven small vessel disease is an early, amyloid-independent feature of PSEN1 E280A familial Alzheimer's disease

Jessica Lisa Villalba-Moreno, Yassir El‐Amri, K I Kim, Nelson David Villalba‐Moreno, Mohsin Shafiq, Carolina Ortiz‐Cordero, Shiwei Wang, Jose Alejandro Ossa, Isaura Suárez-Uribe, Duvan Cardona‐Madrigal, Andrés Villegas, Markus Glatzel, Susanne Krasemann, Rafael Posada‐Duque, Laura L. Kiessling, , Diego Sepúlveda Falla

The paper identifies astrocyte-driven small vessel disease as an early, amyloid-independent feature of PSEN1 E280A familial Alzheimer's disease through proteomic and transcriptomic analyses.

bioRxiv · Jul 22, 2026 · PreprintNeuroscience

Principles of in situ protein sequencing: expansion microscopy-adapted Edman degradation and amino acid recognition

Camille Marie Mitchell, Sara Z. Tavana, Joanne Peng, Hao Wang, Jiuhan Shi, Chi Zhang, Lilia Evgeniou, Masy Domecillo, Shiwei Wang, Daniel Estandian, Alexi G. Choueiri, E. Wong, Sarah Dohadwala, Isken Kenzhebaev, Tay Won Shin, , Edward S. Boyden

This study adapts Edman degradation and amino acid recognition to expansion microscopy gels to demonstrate in situ protein sequencing principles using synthetic constructs.

bioRxiv · Jul 21, 2026 · PreprintBiochemistry

Expansion Revealing of Pathology Resolves Nanostructures Associated with Inflammatory Phenotypes in COVID-19 Decedent Human Brain Tissue

Alice E. Stanton, Jinyoung Kang, Joel Blanchard, Carles A. Boix, Margaret E. Schroeder, Y S Lee, Hanquan Su, Shiwei Wang, Eunah Yu, Amauche Emenari, Zhuyu Peng, Emre Agbas, Oyku Cerit, Demian Park, Ruihan Zhang, , Li‐Huei Tsai

The paper introduces ExRPath and 15ExMPath techniques to expand human brain tissue for nanostructure analysis, revealing amyloid nanoclusters associated with SARS-CoV-2 in COVID-19 patients.

bioRxiv · May 15, 2026 · PreprintNeuroscience

Inactivating a β1 subunit of SnRK1 promotes broad-spectrum disease resistance in rice

Guixin Yuan, Xunli Lu, Xingbin Wang, Mengfei Li, Shiwei Wang, Zhaoxiang Huang, Fengrui Zhang, Xinzhong Zhang, Jun Yang, Hailong Guo, Vijai Bhadauria, Wangsheng Zhu, Wensheng Zhao, You‐Liang Peng

This study shows that disrupting the SnRK1β1A gene in rice confers broad-spectrum resistance to fungal diseases without affecting growth or yield.

bioRxiv · Jun 26, 2025 · PreprintPlant Biology