Chemogenetic Inhibition of the Ventrolateral Orbitofrontal Cortex Disrupts Novelty-Guided Updating of Spatial Memories and Alters Hippocampal Engram Reactivation
K I Kim, Dawnbe Yu, William F Wade…·Stephanie L. Grella
This study shows that ventrolateral orbitofrontal cortex activity is required for updating spatial memories when new information is present, as evidenced by behavioral and hippocampal ensemble impairments.