Author
University of Basel
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
Julia Schedel, Shuo Lin, Thomas Bock, Dominik Bürri, Markus A. Rüegg
This study shows that laminin-α2 is essential for maintaining the myotendinous junction structure, and mechanical unloading affects its integrity in a mouse model of LAMA2-related muscular dystrophy.
Matrix Biology · Mar 17, 2026Peer-reviewedMolecular Biology
Judith R. Reinhard, Shuo Lin, Eleonora Maino, Daniel J. Ham, Markus A. Rüegg
This paper describes a dual AAV gene therapy approach using linker proteins to restore basement membrane function in LAMA2 MD, showing significant improvements in muscle and nerve defects.
Molecular Therapy · Feb 3, 2026Peer-reviewedNeuroscience
Timothy J. McGowan, Judith R. Reinhard, Nicolas Lewerenz, Marta Białobrzeska, Shuo Lin, Jacek Stępniewski, Krzysztof Szade, Józef Dulak, Markus A. Rüegg
This study shows that laminin-α2 secreted by muscle stem cells is critical for their expansion and regeneration, and its loss leads to muscle stem cell dysfunction in LAMA2-related muscular dystrophy.
Nature Communications · Nov 27, 2025Peer-reviewedMolecular Biology
R. Weber, Beatriz Achón Buil, Nora H. Rentsch, Patrick Perron, Stefanie Halliday, Allison Bosworth, Mingzi Zhang, Kassandra Kisler, Chantal Bodenmann, Kathrin J. Zürcher, Daniela Uhr, Debora Meier, Siri L. Peter, Melanie Generali, Shuo Lin, , Ruslan Rust
This study shows that transplanting iPSC-derived neural progenitor cells improves long-term recovery after stroke in mice by promoting tissue repair and reducing neurological deficits.
Nature Communications · Sep 16, 2025Peer-reviewedNeuroscience
Alexander S. Ham, Shuo Lin, Alice Tse, Marco Thürkauf, Timothy J. McGowan, Lena Jörin, Filippo Oliveri, Markus A. Rüegg
The paper uses single-nuclei RNA-sequencing to identify NMJ-specific transcripts and shows that Etv4 and Pdzrn4 contribute to NMJ stability through gene regulation and protein interactions.
Nature Communications · Mar 5, 2025Peer-reviewedMolecular Biology
Jian Tang, Xian Jia, Taoling Zeng, Yuzhou Bao, Yanyan Hu, Junchen Dong, Xiaozheng Xu, Xiao Lei Chen, Yongchao Liu, Jiayu Wang, Bowen Hou, Yuzhen Zhu, Guofeng Fu, Qi‐Fan Zheng, Yongling Chen, , Guo Fu
This study shows Themis regulates T cell exhaustion by controlling TCR and PD-1 signaling, with loss of Themis causing severe immunopathology in chronic viral infection.
bioRxiv · Feb 17, 2025 · PreprintImmunology
Marco Thürkauf, Shuo Lin, Filippo Oliveri, Dirk Grimm, Randall J. Platt, Markus A. Rüegg
This study develops a method to efficiently induce somatic gene deletions in adult mouse skeletal muscle fibers using AAV-CRISPR/Cas9, replicating knockout phenotypes without generating knockout mice.
Nature Communications · Sep 30, 2023Peer-reviewedMolecular Biology
Judith R Reinhard, Emanuela Porrello, Shuo Lin, Paweł Pelczar, Stefano Carlo Previtali, Markus A. Rüegg
This study shows that expressing two linker proteins in mouse models of LAMA2-related muscular dystrophy improves muscle function and prevents hindlimb paralysis.
PNAS Nexus · Mar 15, 2023Peer-reviewedNeuroscience
Alexander S. Ham, Kathrin Chojnowska, Lionel A. J. Tintignac, Shuo Lin, Alexander Schmidt, Daniel J. Ham, Michael Sinnreich, Markus A. Rüegg
This study shows that mTORC1 inhibition in adult mice does not cause muscle atrophy or functional decline, despite metabolic and morphological changes.
bioRxiv · Aug 19, 2019 · PreprintMolecular Biology