Bacteria Hijack a Host Metabolite via Three Distinct Sensors to Orchestrate Infection
Qinmeng Liu, Shuyu Li, Yufei Zhao, Sidi Chen, Heyan Shen, Yayong Yang, Tao Huang, Yongdong Li, Zhiyan Wei, Zhuo Wang, Yi Chen, Lingfang Zhu, Yao Wang, Xihui Shen
This study shows bacteria use three distinct sensors to detect a host metabolite and coordinate infection, with a drug targeting one sensor showing high efficacy against resistant pathogens.
bioRxiv · Jul 31, 2026 · PreprintMicrobiology