Author

Sigrid Schaper

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Assay:CITE-seq· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

Anja DrögeiD· 3 shared Dominik BentsiD· 3 shared Kristin GennermanniD· 3 shared Nadine GenzeliD· 3 shared Steffen HennigiD· 3 shared Volkhard SeitziD· 3 shared Burkhard HirschiD· 2 shared Christina BeushauseniD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Anja DrögeORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Tumor-versus-non-tumor T cell enrichment supported by single-cell and spatial phenotyping enables antigen-agnostic prioritization of candidate tumor-reactive TCRs

Volkhard Seitz, Jannik Franzen, Kristin Gennermann, Burkhard Hirsch, Sigrid Schaper, Anja Dröge, Mathias Dreger, Nadine Genzel, Stephanie Plaßmann, Dominik Bents, Jörn Glökler, Thomas Conrad, Christioph Loddenkemper, Karin Schmelz, Markus Morkel, , Sefer Elezkurtaj

The paper identifies tumor-reactive TCRs using T/N ratios and validates them with single-cell and spatial data, showing their tumor association and effector phenotype.

bioRxiv · Sep 24, 2026 · PreprintImmunology

A new clustering approach identifies tumor-specific common TCRs with pan-cancer reactivity

Steffen Hennig, Kristin Gennermann, Sefer Elezkurtaj, Volkhard Seitz, Burkhard Hirsch, Anja Dröge, Sigrid Schaper, Dominik Bents, Stephan Eggeling, Christina Beushausen, Hermann Herbst, Nadine Genzel, J. Glökler, C. Wölfel, C. Doppler, , R. Hammer

This paper introduces a TCR-V(D)J-sequence clustering method to identify tumor-specific common TCRs across cancers, showing their pan-cancer reactivity and potential for therapeutic applications.

bioRxiv · Apr 26, 2025 · PreprintImmunology

T-cell receptors identified by a personalized antigen-agnostic screening approach target shared neoantigen KRAS Q61H

Volker Lennerz, Christoph Doppler, Martina Fatho, Anja Dröge, Sigrid Schaper, Kristin Gennermann, Nadine Genzel, Stephanie Plaßmann, David Weismann, Samuel W. Lukowski, Dominik Bents, Christina Beushausen, Karen Kriese, Hermann Herbst, Volkhard Seitz, , Steffen Hennig

The paper identifies T-cell receptors targeting KRAS Q61H neoantigen in NSCLC patients using antigen-agnostic screening and demonstrates their reactivity and potential for adoptive cell therapy.

Frontiers in Immunology · Mar 17, 2025Peer-reviewedImmunology