A new clustering approach identifies tumor-specific common TCRs with pan-cancer reactivity
Steffen Hennig, Kristin Gennermann, Sefer Elezkurtaj, Volkhard Seitz, Burkhard Hirsch, Anja Dröge, Sigrid Schaper, Dominik Bents, Stephan Eggeling, Christina Beushausen, Hermann Herbst, Nadine Genzel, J. Glökler, C. Wölfel, C. Doppler, , R. Hammer
This paper introduces a TCR-V(D)J-sequence clustering method to identify tumor-specific common TCRs across cancers, showing their pan-cancer reactivity and potential for therapeutic applications.
bioRxiv · Apr 26, 2025 · PreprintImmunology