Author

Simon J Dovedi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Immunology· 1

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Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Alan KennedyiD· 1 shared Carolina T OrozcoiD· 1 shared Christopher Lloyd· 1 shared Claudia Hinze· 1 shared Dalisay Giovacchini· 1 shared David M SansomiD· 1 shared E. A. Waters· 1 shared Hung-Chang Chen· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Alan KennedyORCID

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1 paper

Recent·Most cited

Rigid, bivalent CTLA-4 binding to CD80 is required to disrupt the cis CD80 / PD-L1 interaction

Maximillian A Robinson, Alan Kennedy, Carolina T Orozco, Hung-Chang Chen, E. A. Waters, Dalisay Giovacchini, Kay Yeung, Lily Filer, Claudia Hinze, Christopher Lloyd, Simon J Dovedi, David M Sansom

This paper shows that rigid, bivalent CTLA-4 binding to CD80 disrupts the cis CD80/PD-L1 interaction, promoting PD-L1 availability through orientation and cross-linking.

bioRxiv · Apr 19, 2024 · PreprintImmunology