David Michael Sansom

This study shows that VPS34 deficiency in regulatory T cells causes a fatal lymphoproliferative disorder by impairing metabolic and functional processes, despite normal development and in vitro suppression.

The paper shows an IL-2 mutein expands regulatory T cells that enhance IL-10 and CTLA-4 to suppress dendritic cells, reducing autoimmunity in NOD mice.

This paper shows that rigid, bivalent CTLA-4 binding to CD80 disrupts the cis CD80/PD-L1 interaction, promoting PD-L1 availability through orientation and cross-linking.

Genomic profiling of CD4 T cell activation reveals a sensitivity switch from TCR in naive to CD28 in memory cells.

The paper quantifies CTLA4 internalization, recycling, and degradation rates using an in vitro-in silico approach and incorporates experimental data from human T cells.