Dhruv Sareen

This study engineers human iPSC-derived neutrophils to express ACE, enhancing their antimicrobial function and reducing bacterial burdens in neutropenic mice.

This paper evaluates combining expression-based surrogate variables and genotype-based principal components in differential expression analysis, finding the combined approach improves replicability and biological recall in ALS datasets.

The paper analyzes ATAC-seq data from iPSC-derived motor neurons of ALS patients and controls to identify disease-specific chromatin accessibility changes and their predictive power for disease progression.

This study identifies sex-based proteomic differences in iPSC-derived vascular smooth muscle cells and their potential impact on cardiovascular disease.

The paper compares TDP-43's transcriptional and splicing effects in muscle and neuronal cells, showing tissue-specific roles in disease.

The paper identifies POM121 as a critical nucleoporin affected by C9orf72 repeat RNA, leading to nuclear pore complex disassembly and neuronal toxicity in ALS/FTD.

The paper uses unsupervised machine learning to identify three molecular subtypes in ALS cortex samples, associated with oxidative stress, retrotransposon activation, and glial activation.

This study compares 3-DGE and conventional mRNAseq, finding similar gene expression results with 3-DGE offering cost savings and scalability.

The paper develops a freezing protocol for ATAC-Seq on motor neurons derived from human induced pluripotent stem cells, showing that slow-cooled cryopreserved samples yield comparable results to fresh cells.