Long-read sequencing quantifies synthetic mRNA abundance, integrity and host response in vivo
Victoria M. McLeod, Daniel Yuen, Moore Z. Chen, Simone A. Beckham, Orlagh M. Feeney, Bruna Rossi Herling, Yifan Yang, Lara M. Mollé, Pharvinderjit Kaur, Thomas J. Payne, Stewart A. Fabb, Colin William Pouton, Christopher J. H. Porter, Angus P. R. Johnston
This paper introduces a long-read sequencing method to directly quantify synthetic mRNA abundance, integrity, and host response in vivo.
bioRxiv · Aug 19, 2026 · PreprintPharmacology & Toxicology