Yifan Yang

Representation-aware calibration enables statistically reliable protein structure search

Struct-Caliper improves protein structure search reliability by providing accurate p-values, increasing homolog recovery and reducing false discoveries compared to native E-values.

Juvenile AAV-Mediated MEF2C Gene Replacement Ameliorates Selected Phenotypes in Mef2c-Haploinsufficient Mice

This study shows that juvenile AAV-mediated MEF2C gene replacement can improve specific phenotypes in Mef2c-haploinsufficient mice.

Maleic acid adjuvates BCG to induce CD4+CD8+ T cells and sterilize tuberculosis

This study shows that maleic acid enhances BCG vaccination to induce CD4+CD8+ T cells that sterilize Mtb infection in mice.

Long-read sequencing quantifies synthetic mRNA abundance, integrity and host response in vivo

This paper introduces a long-read sequencing method to directly quantify synthetic mRNA abundance, integrity, and host response in vivo.

Dimethyl fumarate reprograms cervical cancer cells to enhance antitumor immunity by activating mtDNA-cGAS-STING pathway

This study shows that dimethyl fumarate (DMF) enhances antitumor immunity in cervical cancer by reprogramming tumor cells to activate the mtDNA-cGAS-STING pathway, increasing CD8+ T cell infiltration.

The evaluation of RNA-Seq de novo assembly by PacBio long read sequencing

The paper evaluates RNA-Seq de novo assemblers and evaluation methods using PacBio long reads as a benchmark, finding Trinity is most complete but less continuous, while DETONATE provides a balanced evaluation.

A Powerful Procedure for Pathway-based Meta-Analysis Using Summary Statistics Identifies 43 Pathways Associated with Type II Diabetes in European Populations

This paper introduces sARTP, a pathway-based meta-analysis method using summary statistics, identifying 43 T2D-associated pathways in European populations and 7 trans-ethnic pathways in Asian populations.