Author

Sohini Rebba

Washington University in St. Louis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 3 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Philip A. RuzyckiiD· 3 shared Brian S. ClarkiD· 2 shared Ellen G. Harding· 2 shared Alaina UrmaniD· 1 shared Aleksandra M. KrzywańskaiD· 1 shared Andi K. CaniiD· 1 shared Christy M. HoffmanniD· 1 shared Daniel KerschensteineriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersGenomics

Philip A. RuzyckiORCID

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3 papers

Recent·Most cited

Long read sequencing of retinal RNA improves killifish transcriptome annotation

Sohini Rebba, Lianri Van Schalkwyk, Aleksandra M. Krzywańska, Ryan B. MacDonald, Brian S. Clark, Philip A. Ruzycki

This study improves killifish retinal transcriptome annotation using long-read sequencing, identifying thousands of previously unannotated transcripts and enhancing gene naming accuracy.

bioRxiv · Sep 7, 2026 · PreprintGenomics

A genome-wide in vivo CRISPR screen identifies neuroprotective strategies in the mouse and human retina

Ning Shen, Michael J. Fitzpatrick, Ellen G. Harding, Sohini Rebba, Florentina Soto, Philip A. Ruzycki, Daniel Kerschensteiner

The paper identifies neuroprotective genes in RP using CRISPR screens in mice and human retinal models, showing that UFD1 and UXT overexpression preserves photoreceptors and function.

Neuron · Apr 9, 2026Peer-reviewedNeuroscience

Active DNA demethylation is upstream of rod-photoreceptor fate determination and required for retinal development

Ismael Hernández‐Núñez, Alaina Urman, Xiaodong Zhang, William Jacobs, Christy M. Hoffmann, Sohini Rebba, Ellen G. Harding, Qiang Li, Fengbiao Mao, Andi K. Cani, Shiming Chen, Meelad M. Dawlaty, Rajesh C. Rao, Philip A. Ruzycki, John R. Edwards, Brian S. Clark

The paper shows that DNA demethylation, mediated by TET enzymes, is essential for rod-photoreceptor fate determination during retinal development.

PLoS Biology · Aug 4, 2025Peer-reviewedDevelopmental Biology