Active DNA demethylation is upstream of rod-photoreceptor fate determination and required for retinal development
Ismael Hernández‐Núñez, Alaina Urman, Xiaodong Zhang, William Jacobs, Christy M. Hoffmann, Sohini Rebba, Ellen G. Harding, Qiang Li, Fengbiao Mao, Andi K. Cani, Shiming Chen, Meelad M. Dawlaty, Rajesh C. Rao, Philip A. Ruzycki, John R. Edwards, Brian S. Clark
The paper shows that DNA demethylation, mediated by TET enzymes, is essential for rod-photoreceptor fate determination during retinal development.
PLoS Biology · Aug 4, 2025Peer-reviewedDevelopmental Biology