mTOR driven gene transcription is required for cholesterol production in neurons of the developing cerebral cortex
Martin Schüle, Tamer Butto, Sri Dewi, Laura Schlichtholz, Susanne Strand, Susanne Gerber, Kristina Endres, Susann Schweiger, Jennifer Winter
This study identifies mTORC1 as a transcriptional regulator of cholesterol biosynthesis genes in developing neurons, linking mTOR activity to cholesterol production and neurodevelopmental disorders.
bioRxiv · Sep 4, 2020 · PreprintNeuroscience