DCN1 inhibitor induces fetal hemoglobin through self-limited regulation of CUL3 neddylation
Samuel A. Miller, Anthony Monti, Enhua H. Zhou, Chi Hua Sarah Lin, Orna Lynch, Sayani Mukherjee, Cassie Hei, Robert Nicewonger, Colin Diner, Alejandra Macias-Garcia, Kristen A. Marino, Na Li, Ravi K. Ujjinamatada, Akshay Salegaonkar, Sunil Kuppasani, , Sriram Krishnamoorthy
The paper identifies DCN1 as a therapeutic target for beta-hemoglobinopathies by showing its inhibition increases fetal hemoglobin through selective chromatin changes without cytotoxicity.
bioRxiv · Apr 24, 2026 · PreprintMolecular Biology