Molecular BiologybioRxivPreprint
DCN1 inhibitor induces fetal hemoglobin through self-limited regulation of CUL3 neddylation
Samuel A. Miller, Anthony Monti, Enhua H. Zhou…·Sriram Krishnamoorthy
The paper identifies DCN1 as a therapeutic target for beta-hemoglobinopathies by showing its inhibition increases fetal hemoglobin through selective chromatin changes without cytotoxicity.
DOI 10.64898/2026.04.22.720177