Na Li

Inflammation-induced of Clec18a inhibits immune responses via Trpm7-dependent Cbl activation

This study identifies Clec18a as a regulator of innate immune responses by inhibiting inflammation through Trpm7-dependent Cbl activation.

Genetic canalization of nutrient resorption: evidence from a widespread grass under effective salt stress

In 110 common-garden Phragmites australis genotypes, effective salt stress left N, P and K resorption efficiency largely unchanged; efficiency instead tracked phylogeographic lineage, ecotype and latitude.

STN1 upregulation promotes PARPi resistance in BRCA2-deficient cancer cells via replication fork protection and suppression of ssDNA gap formation

This study identifies STN1 as a factor promoting PARPi resistance in BRCA2-deficient cancer cells by stabilizing replication forks and reducing ssDNA gaps.

PathoBench: an open community-driven benchmark registry for pathogen bioinformatics tools

PathoBench provides a benchmark registry for pathogen bioinformatics tools, enabling standardized evaluation and comparison across 10 pathogens using curated datasets and metrics.

Intracellular Delivery of Peptides and Proteins with an Engineered Membrane Translocation Domain

This paper develops an engineered membrane translocation domain (MTD4) that enables efficient intracellular delivery of peptides and proteins, demonstrating its effectiveness in vitro and in vivo.

DCN1 inhibitor induces fetal hemoglobin through self-limited regulation of CUL3 neddylation

The paper identifies DCN1 as a therapeutic target for beta-hemoglobinopathies by showing its inhibition increases fetal hemoglobin through selective chromatin changes without cytotoxicity.

Hypoglycemia Aggravated Cognitive Degeneration by activating Endothelial ZBP1-mediated PANoptosis in Type 2 Diabetes

This study shows hypoglycemia worsens cognitive decline in type 2 diabetes by triggering endothelial ZBP1-mediated PANoptosis through the AGE-RAGE axis.

Testicular mRNA-LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

This paper develops a spermatocytes-tropic mRNA-LNP delivery system to treat genetic spermatogenic disorders, showing restoration of spermatogenesis in mouse models.

Modulation of antigen delivery and lymph node activation in non-human primates by saponin adjuvant SMNP

This study compares the immune response in non-human primates between alum and SMNP adjuvants, finding SMNP induces stronger humoral responses and enhanced lymph node activation.

Optimization of Alginante- poly-L-lysine Microencapsules Strength by Box-Behnken Model for CHO Culture in Stirred Tank Bioreactor

The paper uses Box-Behnken model to optimize microencapsules strength for CHO cell culture, improving viability and protein production in a stirred tank bioreactor.

Genome-wide Association Study for Number of Vertebrae in an F2 Large White × Minzhu Population of Pigs

The paper conducts a genome-wide association study to identify genetic variants influencing vertebrae number in pigs, finding significant SNPs on SSC1 and SSC7.