Sexually dimorphic effects of mutations in ccRCC driver genes in renal proximal tubule cells
Antonella Catalano, Constanze Kainz, Katharina Moos, Stefan Jaeger, Marvin Müller, Yannick Federkiel, Christian C. Witt, Francesca Cuomo, Alex Waterhölter, Mona Schoberth, Pascal Schlosser, Anna Köttgen, Stefan Haug, Melanie Boerries, Ian J. Frew, Mojca Adlesic
The paper investigates sex-specific effects of Vhl and Vhl/Pbrm1 mutations in renal proximal tubule cells, revealing differences in lipid droplet accumulation and clonal expansion between males and females.
bioRxiv · May 26, 2026 · PreprintCancer Biology