Melanie Boerries

The paper investigates the transcriptional impact of loss of the Y chromosome (LOY) in clear cell renal cell carcinoma (ccRCC) and other cancers, finding minimal effects beyond gene dosage and pathway-level shifts.

This paper develops bispecific costimulators (BiCos) that restore T-cell function in patients treated with bispecific CD3 antibodies, reversing anergy and quiescence through enhanced signaling.

This study uses pan-cancer phosphoproteomics to identify therapeutic targets and improve precision oncology by analyzing 1,998 tumor samples and developing new scores for kinase activity and immune response.

This study identifies hypoxia-associated transcriptional plasticity in IDH-mutant gliomas, showing microglia-driven quiescent-to-activated transitions that drive malignant progression.

This study shows that Smac mimetics induce apoptosis in breast cancer organoids and that necroptosis, associated with inflammation, can be inhibited by LUBAC inhibitors.

This study identifies a Na+-PINK1 signaling pathway that links NMDA receptor activity to mitochondrial fission and caspase-3-dependent synapse elimination during long-term depression.

This study investigates the immunomodulatory effects of SHP2-based vertical RAS pathway inhibition in pancreatic cancer, revealing both immune-activating and suppressive changes that evolve with treatment.

The paper investigates sex-specific effects of Vhl and Vhl/Pbrm1 mutations in renal proximal tubule cells, revealing differences in lipid droplet accumulation and clonal expansion between males and females.

The paper identifies PIF as a placenta-derived peptide that inhibits KV1.3 channels in neutrophils, altering their function during pregnancy.

The paper introduces a therapeutic strategy called castling to correct gene-expression imbalances by rewiring miRNA regulation using the TRIPLE genome-editing technology.

This study shows that small intestine macrophage dynamics control GBS colonization and invasion in infant mice, with region-specific responses to the pathogen.

This study shows that dual SHP2/MEK inhibition in pancreatic cancer causes mitochondrial changes and ROS elevation, leading to a therapy-resistant state that can be targeted with GPX4 inhibition.

This study shows the PIDDosome restricts cardiomyocyte polyploidization during postnatal heart development through p21/Cdkn1a, independent of p53.

This study shows that GATA2 deficiency leads to hematological issues through bone marrow failure and maladaptation, with leukemia arising from genomic instability and proliferation defects.

This study investigates the role of amyloid precursor protein (APP) in synaptic transmission at medial perforant path synapses using organotypic cultures and finds that presynaptic APP affects neurotransmission efficacy.

This study shows that TNF affects excitatory and inhibitory neurotransmission differently at low and high concentrations, with high concentrations activating microglia and inducing homeostatic effects.

The paper develops a generative model to track cell organization changes during PC12 differentiation using static images and shape analysis.